Strain Information | |
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Image | |
BRC No. | RBRC10994 |
Type | Targeted Mutation![]() |
Species | Mus musculus |
Strain name | B6-Tardbp<tm1Koya> |
Former Common name | TDP-DeltaC, TDP-dC |
H-2 Haplotype | |
ES Cell line | RENKA [C57BL/6NCrlCrlj] |
Background strain | |
Appearance | |
Strain development | Developed and deposited by Dr. Koji Yamanaka. Miice were generated using RENKA ES cells (C57BL/6 N). C57BL/6 genetic background. |
Strain description | Kockin mice in which a part of exon 6, encoding amino acid 274-414, was replaced with a 3FLAG tag to delete the C-terminal portion of the encoded protein. |
Colony maintenance | |
References | Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1-Akt signaling pathway. Nishino K, Watanabe S, Shijie J, Murata Y, Oiwa K, Komine O, Endo F, Tsuiji H, Abe M, Sakimura K, Mishra A, Yamanaka K Acta Neuropathol. Commun., 7(1):118 (2019). 31345270 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
FLAG | 3xFLAG tag (synthetic) | 4 | FLAG | ||||
Frt | yeast FRT (flippase recombination target) site | 4 | Frt | ||||
Tardbp MGI:2387629 | TAR DNA binding protein | 4 | Tardbp<tm1Koya> | targeted mutation 1, Koji Yamanaka | |||
neo | neomycin resistance gene (E. coli) | 4 | mouse phosphoglycerate kinase promoter (PGK promoter) |
Phenotype | |
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Phenotype annotation from literatures by Mammalian phenotype ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | phage T7 gb2 promoter, ネオマイシン耐性遺伝子, マウス Phosphoglycerate kinase I(PGK-1)プロモーターおよびポリA配列, 酵母 Saccharomyces cerevisiae FRT配列, 合成DNA FLAG タグ |
Research application | FLP/frt system |
Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Acta Neuropathol Commun., 7(1):118 (2019). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. |
Depositor | Koji Yamanaka (RIKEN) |
Strain Status | ![]() |
Strain Availability | ![]() |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |