Strain Data Sheet
RBRC11285
Strain Information | |
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| Image | |
| BRC No. | RBRC11285 |
| Type | Targeted Mutation |
| Species | Mus musculus |
| Strain name | C57BL/6-Ltb4r1<tm1c(EUCOMM)Hmgu>/Tyoko |
| Former Common name | BLT1-KO, BLT1<flox/flox> |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | |
| Appearance | |
| Strain development | Deposited by Takehiko Yokomizo, Juntendo University in 2021. ES cells obtained from EUCOMM were used. Mice were further crossed with CAG-FLPe Tg mice to generate floxed allele. C57BL/6 genetic background. |
| Strain description | Floexed Ltb4r1 mice. |
| Colony maintenance | |
| References | Leukotriene receptors as potential therapeutic targets. Yokomizo T, Nakamura M, Shimizu T J. Clin. Invest., 128, p2691-2701 (2018). 29757196Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation. Koga T, Sasaki F, Saeki K, Tsuchiya S, Okuno T, Ohba M, Ichiki T, Iwamoto S, Uzawa H, Kitajima K, Meno C, Nakamura E, Tada N, Fukui Y, Kikuta J, Ishii M, Sugimoto Y, Nakao M, Yokomizo T Cell Mol. Immunol., 18(6):1437-1449 (2020). 33037399 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |||||||
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| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| Frt | yeast FRT (flippase recombination target) site | 14 | Frt | ||||
| Ltb4r1 MGI:1309472 | leukotriene B4 receptor 1 | 14 | Ltb4r1<tm1c(EUCOMM)Hmgu> | targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH | |||
| loxP | phage P1 loxP | 14 | loxP | ||||
Phenotype | |
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| Annotation by Mammalian phenotyhpe ontology | |
| Detailed phenotype data | |
Ordering Information | |
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| Donor DNA | バクテリオファージP1 loxP, Saccharomyces cerevisiae FRT |
| Research application | Cre/loxP system FLP/frt system Immunology and Inflammation Research |
| Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cell Mol Immunol. 2020 Oct 9. doi: 10.1038/s41423-020-00559-7. The RECIPIENT must contact the DEPOSITOR in the case of a application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. The RECIPIENT of RBRC11285 shall acknowledge the EUCOMM as the Provider of the ES cells to generate KO mice. |
| Depositor | Takehiko Yokomizo (Juntendo University) |
| Strain Status |  Frozen sperm |
| Strain Availability |  Recovery and QC required prior to distribution |
| Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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| No Data |