Strain Data Sheet

RBRC11286

Strain Information

Image
BRC No.RBRC11286
TypeCRISPR/Cas9Cartagena
SpeciesMus musculus
Strain nameC57BL/6J-Lta4h<em1Tyoko>
Former Common nameLTA4H-KO, Leukotriene A4 hydrolase KO mouse
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeposited by Takehiko Yokomizo, Juntendo University in 2021. C57BL/6J genetic background.
Strain descriptionLta4h mutant mice generated by the CRISPR/Cas9.
Colony maintenance
References
Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation.
Koga T, Sasaki F, Saeki K, Tsuchiya S, Okuno T, Ohba M, Ichiki T, Iwamoto S, Uzawa H, Kitajima K, Meno C, Nakamura E, Tada N, Fukui Y, Kikuta J, Ishii M, Sugimoto Y, Nakao M, Yokomizo T
Cell Mol. Immunol., 18(6):1437-1449.(2020). 33037399

Leukotriene A4 hydrolase deficiency protects mice from diet-induced obesity by increasing energy expenditure through neuroendocrine axis.
Uzawa H, Kohno D, Koga T, Sasaki T, Fukunaka A, Okuno T, Jo-Watanabe A, Kazuno S, Miyatsuka T, Kitamura T, Fujitani Y, Watada H, Saeki K, Yokomizo T
FASEB J., 34(10):13949-13958 (2020). 32844470

Health Report

Examination Date / Room / Rack2023/08/28Room:4-CRack:JSentinel mouse program
2023/05/29Room:4-CRack:JSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Lta4h
MGI:96836		leukotriene A4 hydrolase10Lta4h<em1Tyoko> endonuclease-mediated mutation 1, Takehiko Yokomizo

Phenotype

Annotation by Mammalian phenotyhpe ontology
Detailed phenotype data

Ordering Information

Donor DNA
Research applicationImmunology and Inflammation Research
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cell Mol. Immunol., 18(6):1437-1449.(2020). FASEB J 34, 13949-13958 (2020). The RECIPIENT must contact the DEPOSITOR in the case of a application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
DepositorTakehiko Yokomizo (Juntendo University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: CRISPR/Cas9 genome edited bioresources (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

No Data