Strain Data Sheet
RBRC11289
Strain Information | |
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| Image | |
| BRC No. | RBRC11289 |
| Type | Targeted Mutation |
| Species | Mus musculus |
| Strain name | B6.129-Btg3<tm1Tya> |
| Former Common name | Btg3 (Ana) knockout mouse |
| H-2 Haplotype | |
| ES Cell line | E14.1 [129P2/OlaHsd] |
| Background strain | |
| Appearance | |
| Strain development | Deposited by Tadashi Yamamoto, OIST, in 2021. E14.1 (ES Cell) was used to generate this strain. Mice were further backcrossed to C57BL/6J for 7 or 8 generations. C57BL/6 congenicc strain. |
| Strain description | LacZ reporter mice in which reporter gene cassettes replaced part of exon1 and exon2 of the Btg3 gene. |
| Colony maintenance | |
| References | Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma. Yoneda M, Suzuki T, Nakamura T, Ajima R, Yoshida Y, Kakuta S, Katsuko S, Iwakura Y, Shibutani M, Mitsumori K, Yokota J, Yamamoto T Cancer Sci., 100 (2) 225-32 (2009). 19068083 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |||||||
|---|---|---|---|---|---|---|---|
| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| Btg3 MGI:109532 | BTG anti-proliferation factor 3 | 16 | Btg3<tm1Tya> MGI:3848525 | targeted mutation 1, Tadashi Yamamoto | |||
| GH | Growth hormone polyA (Bovine) | 16 | GH | ||||
| lacZ | beta-galactosidase (E. coli) | 16 | |||||
| loxP | phage P1 loxP | 16 | loxP | ||||
| neo | neomycin resistance gene (E. coli) | 16 | mouse phosphoglycerate kinase promoter (PGK promoter) | ||||
Phenotype | |
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| Annotation by Mammalian phenotyhpe ontology | |
| Detailed phenotype data | |
Ordering Information | |
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| Donor DNA | 大腸菌 Neo, NLS, LacZ, マウス PGK-promoter, ウシ growth hormone polyA付, P1 phage loxP |
| Research application | Cre/loxP system Fluorescent Proteins/lacZ System |
| Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cancer Sci., 100 225-32 (2009). |
| Depositor | Tadashi Yamamoto (Okinawa Institute of Science and Technology Graduate University (OIST)) |
| Strain Status |  Frozen embryos |
| Strain Availability |  Recovery and QC required prior to distribution |
| Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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| No Data |