Strain Data Sheet
RBRC11290
Strain Information | |
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| Image | |
| BRC No. | RBRC11290 |
| Type | Targeted Mutation |
| Species | Mus musculus |
| Strain name | B6.129-Lmtk2<tm1Tya> |
| Former Common name | BREK-KO |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | |
| Appearance | |
| Strain development | Deposited by Tadashi Yamamoto, OIST, in 2021. ES Cells derived from 129Ola were used to generate this strain. Mice were further backcrossed to C57BL/6J for 7 or 8 generations. C57BL/6 congenicc strain. |
| Strain description | Lmtk2 (BREK) Knockout mice. |
| Colony maintenance | |
| References | Azoospermia in mice with targeted disruption of the Brek/Lmtk2 (brain-enriched kinase/lemur tyrosine kinase 2) gene. Kawa S, Ito C, Toyama Y, Maekawa M, Tezuka T, Nakamura T, Nakazawa T, Yokoyama K, Yoshida N, Toshimori K, Yamamoto T Proc. Natl. Acad. Sci. USA, 103(51) 19344-9 (2006). 17158803 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |||||||
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| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| GH | Growth hormone polyA (Bovine) | 5 | GH | ||||
| Lmtk2 MGI:3036247 | lemur tyrosine kinase 2 | 5 | Lmtk2<tm1Tya> MGI:3699255 | targeted mutation 1, Tadashi Yamamoto | |||
| neo | neomycin resistance gene (E. coli) | 5 | mouse phosphoglycerate kinase promoter (PGK promoter) | ||||
Phenotype | |
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| Annotation by Mammalian phenotyhpe ontology | |
| Detailed phenotype data | |
Ordering Information | |
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| Donor DNA | 大腸菌 Neo, マウス PGK-promoter, ウシ growth hormone polyA付 |
| Research application | |
| Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA, 103 (51) 19344-9 (2006). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
| Depositor | Tadashi Yamamoto (Okinawa Institute of Science and Technology Graduate University (OIST)) |
| Strain Status |  Frozen embryos |
| Strain Availability |  Recovery and QC required prior to distribution |
| Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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| No Data |