Strain Data Sheet
RBRC11295
Strain Information | |
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| Image | |
| BRC No. | RBRC11295 |
| Type | Targeted Mutation |
| Species | Mus musculus |
| Strain name | B6.129-Nyap1<tm1Tya> Nyap2<tm1Tya> Myo16<tm1Tya> |
| Former Common name | Nyap1/2/3 triple KO |
| H-2 Haplotype | |
| ES Cell line | E14.1 [129P2/OlaHsd] |
| Background strain | |
| Appearance | |
| Strain development | Deposited by Tadashi Yamamoto, OIST, in 2021. E14.1 ES Cells were used to generate this strain. Mice were further backcrossed to C57BL/6J for 7 or 8 generations. C57BL/6 congenicc strain. |
| Strain description | Triple knockouf mice for Nyap1, Nyap2, Nyap3 (Myo16). |
| Colony maintenance | |
| References | NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. Yokoyama K, Tezuka T, Kotani M, Nakazawa T, Hoshina N, Shimoda Y, Kakuta S, Sudo K, Watanabe K, Iwakura Y, Yamamoto T EMBO J., 30 (23) 4739-54 (2011). 21946561 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |||||||
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| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| Nyap2 MGI:2443135 | neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2 | 1 | Nyap2<tm1Tya> MGI:6107632 | targeted mutation 1, Tadashi Yamamoto | |||
| Nyap1 MGI:2443880 | neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1 | 5 | Nyap1<tm1Tya> MGI:6107631 | targeted mutation 1, Tadashi Yamamoto | |||
| Myo16 MGI:2685951 | myosin XVI | 8 | Myo16<tm1Tya> MGI:6107633 | targeted mutation 1, Tadashi Yamamoto | |||
| GH | Growth hormone polyA (Bovine) | GH | |||||
| loxP | phage P1 loxP | loxP | |||||
| neo | neomycin resistance gene (E. coli) | mouse phosphoglycerate kinase promoter (PGK promoter) | |||||
Phenotype | |
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| Annotation by Mammalian phenotyhpe ontology | |
| Detailed phenotype data | |
Ordering Information | |
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| Donor DNA | 大腸菌 Neo, ファージ loxP, マウス PGK-promoter, ウシ growth hormone polyA付 |
| Research application | Cre/loxP system |
| Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. EMBO J., 30 (23) 4739-54 (2011). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
| Depositor | Tadashi Yamamoto (Okinawa Institute of Science and Technology Graduate University (OIST)) |
| Strain Status |  Frozen embryos |
| Strain Availability |  Recovery and QC required prior to distribution |
| Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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| No Data |