Strain Data Sheet
RBRC11301
Strain Information | |
|---|---|
| Image | |
| BRC No. | RBRC11301 |
| Type | Transgene |
| Species | Mus musculus |
| Strain name | C57BL/6N-Tg(CAG-Mpst)737Rmps |
| Former Common name | Mpst-Tg mouse (Line 737) |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | |
| Appearance | |
| Strain development | Deposited by Takeo Yoshikawa, RIKEN in 2021. C57BL/6N genetic background. |
| Strain description | Transgenic mice expressing HA-tagged mouse Mpst(3-mercaptopyruvate sulfurtransferase) under the control of the CAG promoter. Line 737. |
| Colony maintenance | |
| References | Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology. Ide M, Ohnishi T, Toyoshima M, Balan S, Maekawa M, Shimamoto-Mitsuyama C, Iwayama Y, Ohba H, Watanabe A, Ishii T, Shibuya N, Kimura Y, Hisano Y, Murata Y, Hara T, Morikawa M, Hashimoto K, Nozaki Y, Toyota T, Wada Y, Tanaka Y, Kato T, Nishi A, Fujisawa S, Okano H, Itokawa M, Hirokawa N, Kunii Y, Kakita A, Yabe H, Iwamoto K, Meno K, Katagiri T, Dean B, Uchida K, Kimura H, Yoshikawa T EMBO Mol. Med., 11:e10695 (2020). 31657521 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |||||||
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| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| Amp | Ampicillin resistance gene (E. coli) | UN | Amp | ||||
| HA | human influenza virus HA (hemagglutinin) tag sequence | UN | HA | ||||
| HBB2 | rabbit beta-globin polyA | UN | HBB2 | ||||
| Mpst | mercaptopyruvate sulfurtransferase | UN | Mpst | CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA) | |||
| SV40 polyA | UN | ||||||
Phenotype | |
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| Annotation by Mammalian phenotyhpe ontology | |
| Detailed phenotype data | |
Ordering Information | |
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| Donor DNA | CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA), human influenza virus HA (hemagglutinin) tag sequence, mouse Mpst cDNA, SV40 polyA signal, E. coli pBR322 Replication origin, E. coli Ampicillin resistance gene |
| Research application | Mouse Models for Human Disease |
| Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. EMBO Mol. Med., 11:e10695 (2020).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
| Depositor | Takeo Yoshikawa (RIKEN CBS) |
| Strain Status |  Frozen embryos Frozen sperm |
| Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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| No Data |