Strain Data Sheet

RBRC11303

Strain Information

Image
BRC No.RBRC11303
TypeCRISPR/Cas9Cartagena
SpeciesMus musculus
Strain nameB6N-Cdh23<em1Rmps>
Former Common nameCdh23 KO mouse
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeposited by Takeo Yoshikawa, RIKEN in 2021. This strain was generated by the CRISPR/Cas9. C57BL/6N genetic background.
Strain descriptionCdh23 mutant mice deleting exon 2 of the Cdh23 gene. Model mice for Usher syndrome type 1D (IDs).
Colony maintenance
References
Role of an Atypical Cadherin Gene, Cdh23 in Prepulse Inhibition, and Implication of CDH23 in Schizophrenia.
Balan S, Ohnishi T, Watanabe A, Ohba H, Iwayama Y, Toyoshima M, Hara T, Hisano Y, Miyasaka Y, Toyota T, Shimamoto-Mitsuyama C, Maekawa M, Numata S, Ohmori T, Shimogori T, Kikkawa Y, Hayashi T, Yoshikawa T
Schizophr Bull, 47(4):1190-1200 (2021). 33595068

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cdh23
MGI:1890219		cadherin related 23 (otocadherin)10Cdh23<em1Rmps> endonuclease-mediated mutation 1, Takeo Yoshikawa
  • autosomal recessive nonsyndromic hearing loss 12(DisGeNET, MedGEN)

  • pituitary adenoma 5, multiple types(MedGEN)

  • Usher syndrome type 1D(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAStreptococcus pyogenes Cas9n mRNA (マウス個体においてRNAの残存の有無を確認していない), Streptococcus pyogenes sgRNAの標的配列以外の部分　(マウス個体においてRNAの残存の有無を確認していない)
    Research applicationMouse Models for Human Disease
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
    DepositorTakeo Yoshikawa (RIKEN CBS)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: CRISPR/Cas9 genome edited bioresources (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data