Strain Data Sheet
RBRC11314
Strain Information | |
|---|---|
| Image | |
| BRC No. | RBRC11314 |
| Type | Transgene |
| Species | Mus musculus |
| Strain name | C57BL/6JJcl-Tg(CnCda2-TCR)Tukk |
| Former Common name | CnT-II |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | |
| Appearance | |
| Strain development | Deposited by Keiko Ishii and Kazuyoshi Kawakami, Tohoku University in 2021. TG mice were generated using the fertilized eggs derived from (C57BL/6 x DBA/2)F1. Mice were further backcrossed to C57BL/6J for more than 18 generations. C57BL/6 congenic line. |
| Strain description | Transgenic mice expressing TCR recognizing chitin deacetylase of Cryptococcus neoformans. |
| Colony maintenance | |
| References | Production of IL-17A at Innate Immune Phase Leads to Decreased Th1 Immune Response and Attenuated Host Defense against Infection with Cryptococcus deneoformans. Sato K, Yamamoto H, Nomura T, Kasamatsu J, Miyasaka T, Tanno D, Matsumoto I, Kagesawa T, Miyahara A, Zong T, Oniyama A, Kawamura K, Yokoyama R, Kitai Y, Ishizuka S, Kanno E, Tanno H, Suda H, Morita M, Yamamoto M, Iwakura Y, Ishii K, Kawakami K J. Immunol., 205(3):686-698 (2020). 32561568 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |||||||
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| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| HBB | human beta-globin | UN | HBB | ||||
| Igh | mouse immunoglobulin heavy chain enhancer (IgH) | UN | Igh | ||||
| Tcra | T cell receptor alpha chain | UN | Tcra | mouse H-2Kb promoter | |||
| Tcrb | T cell receptor beta chain | UN | Tcrb | mouse H-2Kb promoter | |||
Phenotype | |
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| Annotation by Mammalian phenotyhpe ontology | |
| Detailed phenotype data | |
Ordering Information | |
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| Donor DNA | mouse H-2Kb promoter, mouse T-cell receptor (TCR) alpha and beta, human beta-globin genomic DNA, (poly A), mouse immunoglobulin heavy chain enhancer (IgH) |
| Research application | Immunology and Inflammation Research |
| Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Immunol., 205(3):686-698 (2020). |
| Depositor | Kazuyoshi Kawakami (Tohoku University) |
| Strain Status |  Frozen sperm |
| Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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| No Data |