Strain Data Sheet
RBRC11315
Strain Information | |
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| Image | |
| BRC No. | RBRC11315 |
| Type | Targeted Mutation |
| Species | Mus musculus |
| Strain name | C57BL/6-Cadps2<tm1.1Ksak> |
| Former Common name | Cadps2-flox knock-in mice |
| H-2 Haplotype | |
| ES Cell line | RENKA [C57BL/6NCrlCrlj] |
| Background strain | |
| Appearance | |
| Strain development | Deposited by Teiichi Furuichi, Tokyo University of Science in 2021. Mice were generated using RENKA ES cells. C57BL/6 genetic background |
| Strain description | Cadps2 floxed mice. A pair of loxP flanks exon 6. |
| Colony maintenance | |
| References | Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients. Sadakata T, Washida M, Iwayama Y, Shoji S, Sato Y, Ohkura T, Katoh-Semba R, Nakajima M, Sekine Y, Tanaka M, Nakamura K, Iwata Y, Tsuchiya K J, Mori N, Detera-Wadleigh S D, Ichikawa H, Itohara S, Yoshikawa T, Furuichi T J. Clin. lnvest., 117, 931-943 (2007) . 17380209Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in neurotrophin release. Sadakata T, Kakegawa W, Mizoguchi A, Washida M, Katoh-Semba R, Shutoh F, Okamoto T, Nakashima H, Kimura K, Tanaka M, Sekine Y, Itohara S, Yuzaki M, Nagao S, Furuichi T J. Neurosci., 27, 2472-2482 (2007). 17344385CAPS2 Deficiency Impairs the Release of the Social Peptide Oxytocin, as Well as Oxytocin-Associated Social Behavior. Shuhei Fujima, Ryosuke Yamaga, Haruka Minami, Shota Mizuno, Yo Shinoda, Tetsushi Sadakata, Manabu Abe, Kenji Sakimura, Yoshitake Sano, Teiichi Furuichi J. Neurosci., 41(20):4524-4535 (2021). 33846232CAPS2 Deficiency Impairs the Release of the Social Peptide Oxytocin, as Well as Oxytocin-Associated Social Behavior. Fujima S, Yamaga R, Minami H, Mizuno S, Shinoda Y, Sadakata T, Abe M, Sakimura K, Sano Y, Furuichi T J. Neurosci., 41(20):4524-4535 (2021). 33846232 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |||||||
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| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| Cadps2 MGI:2443963 | Ca2+-dependent activator protein for secretion 2 | 6 | Cadps2<tm1.1Ksak> MGI:6764588 | targeted mutation 1.1, Kenji Sakimur | |||
| Frt | yeast FRT (flippase recombination target) site | 6 | Frt | ||||
| loxP | phage P1 loxP | 6 | loxP | ||||
| loxP | phage P1 loxP | 6 | loxP | ||||
Phenotype | |
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| Annotation by Mammalian phenotyhpe ontology | |
| Detailed phenotype data | |
Ordering Information | |
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| Donor DNA | P1 Phage (class 1) loxP sites (M10287), Saccharomyces cerevisiae (class 1) FRT site(J01347.1), Mus musculus CAPS2/Cadps2 genomic DNA(NM_153163) |
| Research application | Cre/loxP system FLP/frt system |
| Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J Neurosci. 2021 May 19;41(20):4524-4535. doi: 10.1523/JNEUROSCI.3240-20.2021.Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEVELOPER (Dr. Kenji Sakimura; sakimura@bri.niigata-u.ac.jp) using the Approval Form. |
| Depositor | Teiichi furuichi (Tokyo University of Science) |
| Strain Status |  Frozen sperm |
| Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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| No Data |