Strain Information | |
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Image | |
BRC No. | RBRC11316 |
Type | Targeted Mutation![]() |
Species | Mus musculus |
Strain name | C57BL/6-Oxt<tm1.1(Cre)Ksak> |
Former Common name | Oxt-iCre knock-in mice |
H-2 Haplotype | |
ES Cell line | RENKA [C57BL/6NCrlCrlj] |
Background strain | |
Appearance | |
Strain development | Deposited by Teiichi Furuichi, Tokyo University of Science in 2021. Mice were generated using RENKA ES cells. C57BL/6 genetic background |
Strain description | Cre knock-in mice at exon3 of the Oxt gene. |
Colony maintenance | |
References | CAPS2 Deficiency Impairs the Release of the Social Peptide Oxytocin, as Well as Oxytocin-Associated Social Behavior. Shuhei Fujima, Ryosuke Yamaga, Haruka Minami, Shota Mizuno, Yo Shinoda, Tetsushi Sadakata, Manabu Abe, Kenji Sakimura, Yoshitake Sano, Teiichi Furuichi J. Neurosci., 41(20):4524-4535 (2021). 33846232CAPS2 Deficiency Impairs the Release of the Social Peptide Oxytocin, as Well as Oxytocin-Associated Social Behavior. Fujima S, Yamaga R, Minami H, Mizuno S, Shinoda Y, Sadakata T, Abe M, Sakimura K, Sano Y, Furuichi T J. Neurosci., 41(20):4524-4535 (2021). 33846232Oxytocinergic projection from the hypothalamus to supramammillary nucleus drives recognition memory in mice. Junpei Takahashi, Daisuke Yamada, Wakana Nagano, Yoshitake Sano, Teiichi Furuichi, Akiyoshi Saitoh PLoS One, 18(11) e0294113 (2023). 37971993 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
F2A | foot-and-mouth disease virus (FMD) 2A peptide | 2 | F2A | ||||
Frt | yeast FRT (flippase recombination target) site | 2 | Frt | ||||
Oxt MGI:97453 | oxytocin | 2 | Oxt<tm1.1(cre)Ksak> | targeted mutation 1.1, Kenji Sakimura | |||
icre | phage P1 codon improved Cre (iCre) | 2 | icre | ||||
SV40 polyA | 2 |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | Saccharomyces cerevisiae FRT (flippase recombination target) site(J01347.1), Foot-and-mouth disease virus (FMDV derived) 2A peptide (F2A)(Coxsackievirus)(class 2), P1 Phage (class 1) iCre recombinase (YP_006472), SV40 (class 2) polyA, mouse Oxytocin (NM_011025.3)genomic DNA |
Research application | Cre/loxP system |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J Neurosci. 2021 May 19;41(20):4524-4535. doi: 10.1523/JNEUROSCI.3240-20.2021.利用者は提供承諾書を用いて、事前に開発者(﨑村健司博士; sakimura@bri.niigata-u.ac.jp)の承諾を得る。 |
Depositor | Teiichi furuichi (Tokyo University of Science) |
Strain Status | ![]() |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- Mouse of the Month Aug 2022 |
BRC mice in Publications |
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No Data |