Strain Data Sheet

RBRC11316

Strain Information

Image
BRC No.RBRC11316
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC57BL/6-Oxt<tm1.1(Cre)Ksak>
Former Common nameOxt-iCre knock-in mice
H-2 Haplotype
ES Cell lineRENKA [C57BL/6NCrlCrlj]
Background strain
Appearance
Strain developmentDeposited by Teiichi Furuichi, Tokyo University of Science in 2021. Mice were generated using RENKA ES cells. C57BL/6 genetic background
Strain descriptionCre knock-in mice at exon3 of the Oxt gene.
Colony maintenance
References
CAPS2 Deficiency Impairs the Release of the Social Peptide Oxytocin, as Well as Oxytocin-Associated Social Behavior.
Shuhei Fujima, Ryosuke Yamaga, Haruka Minami, Shota Mizuno, Yo Shinoda, Tetsushi Sadakata, Manabu Abe, Kenji Sakimura, Yoshitake Sano, Teiichi Furuichi
J. Neurosci., 41(20):4524-4535 (2021). 33846232

CAPS2 Deficiency Impairs the Release of the Social Peptide Oxytocin, as Well as Oxytocin-Associated Social Behavior.
Fujima S, Yamaga R, Minami H, Mizuno S, Shinoda Y, Sadakata T, Abe M, Sakimura K, Sano Y, Furuichi T
J. Neurosci., 41(20):4524-4535 (2021). 33846232

Oxytocinergic projection from the hypothalamus to supramammillary nucleus drives recognition memory in mice.
Junpei Takahashi, Daisuke Yamada, Wakana Nagano, Yoshitake Sano, Teiichi Furuichi, Akiyoshi Saitoh
PLoS One, 18(11) e0294113 (2023). 37971993

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
F2A foot-and-mouth disease virus (FMD) 2A peptide2F2A
Frt yeast FRT (flippase recombination target) site2Frt
Oxt
MGI:97453
oxytocin2Oxt<tm1.1(cre)Ksak> targeted mutation 1.1, Kenji Sakimura
  • neurohypophyseal diabetes insipidus(MedGEN)
  • icre phage P1 codon improved Cre (iCre)2icre
    SV40 polyA2

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNASaccharomyces cerevisiae FRT (flippase recombination target) site(J01347.1), Foot-and-mouth disease virus (FMDV derived) 2A peptide (F2A)(Coxsackievirus)(class 2), P1 Phage (class 1) iCre recombinase (YP_006472), SV40 (class 2) polyA, mouse Oxytocin (NM_011025.3)genomic DNA
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J Neurosci. 2021 May 19;41(20):4524-4535. doi: 10.1523/JNEUROSCI.3240-20.2021.利用者は提供承諾書を用いて、事前に開発者(﨑村健司博士; sakimura@bri.niigata-u.ac.jp)の承諾を得る。
    DepositorTeiichi furuichi (Tokyo University of Science)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-
    Mouse of the Month Aug 2022

    BRC mice in Publications

    No Data