Strain Data Sheet

RBRC11321

Strain Information

Image
BRC No.RBRC11321
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6J.B6N-Tg(Fabp4-Gpnmb)1Jwada
Former Common nameGpnmb Tg mouse
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeposited by Jun Wada, Okayama University in 2021. C57BL/6 genetic background.
Strain descriptionTransgenic mice expression Gpnmb under the control of Fabp4 gene promoter.
Colony maintenance
References
Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis.
Katayama A, Nakatsuka A, Eguchi J, Murakami K, Teshigawara S, Kanzaki M, Nunoue T, Hida K, Wada N, Yasunaka T, Ikeda F, Takaki A, Yamamoto K, Kiyonari H, Makino H, Wada J
Sci. Rep., 5:16920 (2015). 26581806

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Gpnmb glycoprotein (transmembrane) nmbUNGpnmb

Phenotype

Annotation by Mammalian phenotyhpe ontology
Detailed phenotype data

Ordering Information

Donor DNAmouse AP2 promoter(AC_000025.1; 10238852-10244288), rabbit Beta-globin intron (K03256), mouse Gpnmb cDNA(transmembrane glycoprotein NMB precursor) (NM_053110.4), human GH polyA signal(E00140, 20111-2116)
Research application
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Sci. Rep., 5:16920 (2015). In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Ace.No. CDB0503T and Web. Site (https://large.riken.jp/distribution/mutant-list.html) is requested. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested (Sci Rep. 5:16920. doi:10.1038/srep16920). Please inform the DEPOSITOR (mutant.bdr@riken.jp) about the paper when published.
DepositorJun Wada (Okayama University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

No Data