Strain Data Sheet
RBRC11342
Strain Information | |
|---|---|
| Image | |
| BRC No. | RBRC11342 |
| Type | Targeted Mutation |
| Species | Mus musculus |
| Strain name | Epac2 (Acc No. CDB0570K) |
| Former Common name | Epac2 (Acc No. CDB0570K) |
| H-2 Haplotype | |
| ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
| Background strain | |
| Appearance | |
| Strain development | |
| Strain description | |
| Colony maintenance | |
| References | Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses. Satoshi Okumura, Takayuki Fujita, Wenqian Cai, Meihua Jin, Iyuki Namekata, Yasumasa Mototani, Huiling Jin, Yoshiki Ohnuki, Yayoi Tsuneoka, Reiko Kurotani, Kenji Suita, Yuko Kawakami, Shogo Hamaguchi, Takaya Abe, Hiroshi Kiyonari, Takashi Tsunematsu, Yunzhe Bai, Sayaka Suzuki, Yuko Hidaka, Masanari Umemura, Yasuhiro Ichikawa, Utako Yokoyama, Motohiko Sato, Fumio Ishikawa, Hiroko Izumi-Nakaseko, Satomi Adachi-Akahane, Hikaru Tanaka, Yoshihiro Ishikawa J. Clin. Invest., 124(6):2785-801 (2014). 24892712 |
Health Report | |
|---|---|
| Examination Date / Room / Rack | |
Gene | |||||||
|---|---|---|---|---|---|---|---|
| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| Rapgef4 MGI:1917723 | Rap guanine nucleotide exchange factor (GEF) 4 | 2 | Rapgef4<tm1Yish> MGI:5638899 | targeted mutation 1, Yoshihiro Ishikawa | |||
| loxP | phage P1 loxP | 2 | loxP | ||||
| neo | neomycin resistance gene (E. coli) | 2 | mouse phosphoglycerate kinase promoter (PGK promoter) | ||||
Phenotype | |
|---|---|
| Annotation by Mammalian phenotyhpe ontology | |
| Detailed phenotype data | |
Ordering Information | |
|---|---|
| Donor DNA | Neo：大腸菌由来、loxP：P1ﾌｧｰｼﾞ由来、PGKプロモーター,PGK 3’end：マウス由来 |
| Research application | Cre/loxP system |
| Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Clin. Invest., 124(6):2785-801 (2014).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The availability of the BIOLOGICAL RESOURCE is restricted to a RECIPIENT of a not-for organization for a not-for-profit research. The RECIPIENT shall obtain a prior agreement from the DEVELOPER(Yoshihiro Ishikawa yishikaw@med.yokohama-cu.ac.jp) to transfer the BIOLOGICAL RESOURCE. For use of the BIOLOGICAL RESOURCE by a for-profit organization or by a not-for profit organization for a for-profit research, the RECIPIENT must reach agreement on Terms and Conditions of use of it with the DEPOSITOR (mutant.bdr@riken.jp) and must obtain a prior written consent from the DEPOSITOR. Please inform the DEPOSITOR about the paper when published. |
| Depositor | Hiroshi Kiyonari (RIKEN BDR) |
| Strain Status |  Frozen embryos |
| Strain Availability |  Recovery and QC required prior to distribution |
| Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
|---|
| No Data |