Strain Data Sheet

RBRC11360

Strain Information

Image
BRC No.RBRC11360
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129-Sall1<tm4.1Ryn>/#166-29
Former Common nameSalll flox (#166-29, #166-25)
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strain
Appearance
Strain developmentDeposited by Ryuichi Nishinakamura, Kumamoto University in 2021. This strain was generated using E14.1 (ES Cell) derived from 129P2/OlaHsd. Mice were further backcrossed to C57BL/6J for 2 generations.
Strain descriptionSall1floxed mice. #166-25 was used for further analysis instead of #166-29.
Colony maintenance
References
Sall4 is essential for stabilization, but not for pluripotency, of embryonic stem cells by repressing aberrant trophectoderm gene expression.
Yuri S, Fujimura S, Nimura K, Takeda N, Toyooka Y, Fujimura Y, Aburatani H, Ura K, Koseki H, Niwa H, Nishinakamura R
Stem Cells, 27(4):796-805 (2009). 19350679

Sall1 maintains nephron progenitors and nascent nephrons by acting as both an activator and a repressor.
Kanda S, Tanigawa S, Ohmori T, Taguchi A, Kudo K, Suzuki Y, Sato Y, Hino S, Sander M, Perantoni A O, Sugano S, Nakao M, Nishinakamura R
J. Am. Soc. Nephrol., 25(11):2584-95 (2014). 24744442

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Sall1
MGI:1889585		spalt like transcription factor 18Sall1<tm4.1Ryn>
MGI:4443121		targeted mutation 4.1, Ryuichi Nishinakamura
  • Townes-Brocks syndrome 1(MedGEN)

  • Townes-Brocks syndrome(DisGeNET)
    • loxP phage P1 loxP8loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAP1 phage LoxP配列
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Am. Soc. Nephrol., 25(11):2584-95 (2014). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. For use of the BIOLOGICAL RESOURCE by a for-profit organization or commercial users, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. RECIPIENT must contact the DEPOSITOR in the case of a application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorRyuichi Nishinakamura (Kumamoto University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data