Strain Information | |
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Image | |
BRC No. | RBRC11386 |
Type | Transgene Congenic![]() |
Species | Mus musculus |
Strain name | B6;Cg-Tg(Ctsk-OCZF)#Akt |
Former Common name | |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Deposited by Akiko Kukita, Saga University in 2021. This strain was generated using fertilized eggs derived from B6D2F1 and the mice were further backcrossed to C57BL/6N for three generations. Mixed genetic background. |
Strain description | Transgenic mice expressing rat OCZF/LRF/FBI-1 under the control of mouse cathepsin K promoter. |
Colony maintenance | |
References | Osteoclast-derived zinc finger (OCZF) protein with POZ domain, a possible transcriptional repressor, is involved in osteoclastogenesis. Kukita A, Kukita T, Ouchida M, Maeda H, Yatsuki H, Kohashi O Blood, 94(6):1987-97 (1999). 10477728The transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivo. Kukita A, Kukita T, Nagata K, Teramachi J, Li Y J, Yoshida H, Miyamoto H, Gay S, Pessler F, Shobuike T Arthritis Rheum., 63(9):2744-54 (2011). 21590684 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
EGFP | Enhanced Green Fluorescent Protein (Aequorea victoria) | UN | EGFP | ||||
HBB | human beta-globin | UN | HBB | ||||
Ires | internal ribosomal entry site (EMCV) | UN | |||||
ZBTB7A | zinc finger and BTB domain containing 7a (rat) | UN | ZBTB7A | mouse Cathepsin K promoter | |||
SV40 polyA signal | UN |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | mouse Cathepsin K promoter, human 5'-donor site from the first intron of the human beta-globin gene and the branch and 3'-acceptor site from the intron of an immunoglobulin gene heavy chain variable region, rat OCZF cDNA, encephalomyocarditis virus, EMCV internal ribosomal entry site (IRES), Aequorea victoria enhanced green fluorescent protein (EGFP)cDNA, SV 40 poly A signal |
Research application | Fluorescent Proteins/lacZ System |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Arthritis Rheum., 63(9):2744-54 (2011). |
Depositor | Akiko Kukita (Saga University) |
Strain Status | ![]() |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |