Strain Data Sheet

RBRC11390

Strain Information

Image
BRC No.RBRC11390
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Cxcl12<tm4.1Tng>
Former Common nameCxcl12-flox
H-2 Haplotype
ES Cell lineKY1.1[(C57BL/6J x 129S6/SvEvTac)F1]
Background strain
Appearance
Strain developmentDeposited by Takashi Nagasawa, Osaka University in 2021. This strain was generated using KY1.1 ES cells derived from 129/B6. Mice were further backcrossed to C57BL/6J for 10 generations. C57BL/6J congenic line.
Strain descriptionCxcl12-flox mouse. Exon 2 of the Cxcl12 gene is floxed by a pair of loxP.
Colony maintenance
References

Health Report

Examination Date / Room / Rack2024/01/09Room:3-BRack:DSentinel mouse program
2023/10/10Room:3-BRack:DSentinel mouse program
2023/07/10Room:3-BRack:DSentinel mouse program
2023/04/10Room:3-BRack:DSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cxcl12
MGI:103556		C-X-C motif chemokine ligand 126Cxcl12<tm4.1Tng> targeted mutation 4.1, Takashi Nagasawa
  • susceptibility to HIV infection(MedGEN)
    • loxP phage P1 loxP6loxP
    loxP phage P1 loxP6loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAP1 phage loxP sites, mouse Cxcl12 genomic DNA
    Research applicationCre/loxP system
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. RECIPIENT which wants to use the BIOLOGICAL RESOURCE is requested to contact the depositor (Dr. Takashi Nagasawa) and enter into a Material Transfer Agreement with Osaka University. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR.
    DepositorTakashi Nagasawa (Osaka University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Co-creation Bureau, Osaka University HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data