Strain Information | |
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Image | |
BRC No. | RBRC11431 |
Type | Targeted Mutation Congenic |
Species | Mus musculus |
Strain name | B6;Cg-Flt1<tm1Msh> |
Former Common name | FLT1<TK-/-> mice, FLT1TK<+/-> mice |
H-2 Haplotype | |
ES Cell line | J1 [129S4/SvJae] |
Background strain | |
Appearance | |
Strain development | Deposited by Masabumi Shibuya, Jobu University in 2021. This strain was generated using J1 (ES Cell) derived from 129S4/SvJae. Mice were backcrossed to C57BL.6 for several generations. Mixed genetic background. |
Strain description | Flt1 mutant mice lacking kinase domain. |
Colony maintenance | |
References | Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Hiratsuka S, Minowa O, Kuno J, Noda T, Shibuya M Proc. Natl. Acad. Sci. USA, 95(16):9349-54 (1998). 9689083Vascular endothelial growth factor receptor-1 signaling promotes mobilization of macrophage lineage cells from bone marrow and stimulates solid tumor growth. Muramatsu M, Yamamoto S, Osawa T, Shibuya M Cancer Res., 70(20):8211-21 (2010). 20924106Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocytes/macrophages. Murakami M, Iwai S, Hiratsuka S, Yamauchi M, Nakamura K, Iwakura Y, Shibuya M Blood, 108(6):1849-56 (2006). 16709927A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain. Selvaraj D, Gangadharan V, Michalski C W, Kurejova M, Stosser S, Srivastava K, Schweizerhof M, Waltenberger J, Ferrara N, Heppenstall P, Shibuya M, Augustin H G, Kuner R Cancer Cell., 27(6):780-96 (2015). 26058077MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis. Hiratsuka S, Nakamura K, Iwai S, Murakami M, Itoh T, Kijima H, Shipley J M, Senior R M, Shibuya M Cancer Cell, 2(4):289-300 (2002). 12398893 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Flt1 | FMS-like tyrosine kinase 1 | 5 | Flt1 | targeted mutation 1, Masabumi Shibuya | |||
neo | neomycin resistance gene (E. coli) | 5 | mouse Phosphoglycerate kinase (PGK) promoter |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | mouse Phosphoglycerate kinase (PGK) promoter, E. coli Neomycin-resistant gene, Mouse FLT1 gene: Part of Intron-16, -17 genomic DNA |
Research application | Mouse Models for Human Disease |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc Natl Acad Sci USA., 95(16):9349-54 (1998). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. (from the Deposition time on 2021 year to 2023y.3.31. After that, there is no requirement for this item.) |
Depositor | Masabumi Shibuya (Jobu University) |
Strain Status | Live mice |
Strain Availability | Recovery and QC required prior to distribution |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |