Strain Data Sheet

RBRC11433

Strain Information

Image
BRC No.RBRC11433
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129-Kdr<tm1.1Msh>
Former Common nameFLK1<1173F/+> mice、FLK1<1173F/1173F> mice
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearance
Strain developmentDeposited by Masabumi Shibuya, Jobu University in 2021. This strain was generated using E14 (ES Cell) derived from 129P2/OlaHsd. Mice were backcrossed to C57BL.6 for several generations. Mixed genetic background.
Strain descriptionKdr mutant harboring a point mutation (Y1173F) in the Kdr gene. A neo gene was deleted by CAG-Cre cross.
Colony maintenance
References
Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice.
Sakurai Y, Ohgimoto K, Kataoka Y, Yoshida N, Shibuya M
Proc. Natl. Acad. Sci. USA, 102, 1076-1081 (2005). 15644447

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Kdr
MGI:96683		kinase insert domain protein receptor5Kdr<tm1.1Msh>
MGI:3530468		targeted mutation 1.1, Masabumi Shibuya
  • capillary infantile hemangioma(MedGEN)
    • loxP phage P1 loxP5loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAP1 phage loxP, Mouse FLK1 gene: 変異Exon-27 (1173部位コドンの変異を含む)
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA., 102, 1076-1081 (2005).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorMasabumi Shibuya (Jobu University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data