Strain Data Sheet

RBRC11441

Strain Information

Image
BRC No.RBRC11441
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Kdm6b<tm1.1Masn>
Former Common name129B6-Jmjd3(Kdm6b) kncokout mice
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strain
Appearance
Strain developmentDeposited by Masahide Asano, Kyoto University in 2021. This strain was generated using E14 ES cells derived from 129P2/OlaHsd and then mice were crossed to C57BL/6J once. Mixed genetic background.
Strain descriptionJmjd3(Kdm6b)knockout mice lacking exon 18 of the Jmjd3(Kdm6b) gene. Homozygous mutant are neonatally lethal.
Colony maintenance
References
New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice.
Naruse C, Shibata S, Tamura M, Kawaguchi T, Abe K, Sugihara K, Kato T, Nishiuchi T, Wakana S, Ikawa M, Asano M
FASEB J., 31(6):2252-2266 (2017). 28188179

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Frt yeast FRT (flippase recombination target) site11Frt
Ires internal ribosomal entry site (EMCV)11
Kdm6b
MGI:2448492		KDM1 lysine (K)-specific demethylase 6B11Kdm6b<tm1.1Masn>
MGI:6277129		targeted mutation 1.1, Masahide Asano
  • neurodevelopmental disorder with coarse facies and mild distal skeletal abnormalities(MedGEN)
    • loxP phage P1 loxP11loxP
    neo neomycin resistance gene (E. coli)11

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNABacteriophage P1 loxP sites, Saccharomyces cerevisiae FRT sites, Mouse En-2 splicing acceptor, encephalomyocarditis virus Internal ribosomal entry site, E. coli Neomycin resistant gene, Bovine polyA signal
    Research applicationCre/loxP system
    FLP/frt system
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. FASEB J., 31(6):2252-2266 (2017). doi: 10.1096/fj.201600642R.In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of a application for an patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Masahide Asano and Dr. Chie Naruse is requested. (Contact info: Dr. Masahide Asano <asano@anim.med.kyoto-u.ac.jp>, Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University)
    DepositorMasahide Asano (Kyoto University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data