Strain Data Sheet

RBRC11442

Strain Information

Image
BRC No.RBRC11442
TypeCRISPR/Cas9Cartagena
SpeciesMus musculus
Strain nameB6;B6D2-Kdm6b<em1Masn>
Former Common nameB6-Jmjd3em demethylase mutant mice
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeposited by Masahide Asano, Kyoto University in 2021. This strain was generated using E14 ES cells derived from B6D2F1 x C57BL/6 cross and then mice were crossed to C57BL/6J twice. Mixed genetic background.
Strain descriptionJmjd3(Kdm6b)muant mice lacking the splice acceptor of exon 18 of the Jmjd3(Kdm6b) gene. Homozygous mutant are neonatally lethal.
Colony maintenance
References
New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice.
Naruse C, Shibata S, Tamura M, Kawaguchi T, Abe K, Sugihara K, Kato T, Nishiuchi T, Wakana S, Ikawa M, Asano M
FASEB J., 31(6):2252-2266 (2017). 28188179

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Kdm6b
MGI:2448492		KDM1 lysine (K)-specific demethylase 6B11Kdm6b<em1Masn>
MGI:6277163		endonuclease-mediated mutation 1, Masahide Asano
  • neurodevelopmental disorder with coarse facies and mild distal skeletal abnormalities(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. FASEB J., 31(6):2252-2266 (2017). doi: 10.1096/fj.201600642R.In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of a application for an patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Masahide Asano and Dr. Chie Naruse is requested. (Contact info: Dr. Masahide Asano <asano@anim.med.kyoto-u.ac.jp>, Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University)
    DepositorMasahide Asano (Kyoto University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: CRISPR/Cas9 genome edited bioresources (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data