Strain Data Sheet
RBRC11527
Strain Information | |
|---|---|
| Image | |
| BRC No. | RBRC11527 |
| Type | Transgene |
| Species | Mus musculus |
| Strain name | C57BL/6J-Tg(CAG-cat,-Gdf10)1Ncvcb |
| Former Common name | BMP-3b Tg (Bone morphogenetic protein-3b (BMP-3b) transgenic mice in which expression of BMP-3b was tissue specific and Cre-inducible) |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | |
| Appearance | |
| Strain development | Deposited by Jun Hino, National Cerebral and Cardiovascular Center Hospital in 2021. C57BL/6J genetic background. |
| Strain description | Transgenic mice expressing growth differentiation factor 10 (Bmp3b) under the control of CAG promoter. and CAG and Gdf10 are separated by a floxed cat. |
| Colony maintenance | |
| References | Overexpression of bone morphogenetic protein-3b (BMP-3b) in adipose tissues protects against high-fat diet-induced obesity. Hino J, Nakatani M, Arai Y, Tsuchida K, Shirai M, Miyazato M, Kangawa K Int. J. Obes. (Lond)., 41(4):483-488 (2017). 28104917 |
Health Report | |
|---|---|
| Examination Date / Room / Rack | 2024/09/09Room:3-2Rack:ASentinel mouse program 2024/06/10Room:3-2Rack:ASentinel mouse program 2024/03/11Room:3-2Rack:ASentinel mouse program 2023/12/11Room:3-2Rack:ASentinel mouse program 2023/09/11Room:3-2Rack:ASentinel mouse program 2023/06/26Room:3-2Rack:AAdditional tests 2023/06/13Room:3-2Rack:ASentinel mouse program 2023/03/13Room:3-2Rack:ASentinel mouse program |
Gene | |||||||
|---|---|---|---|---|---|---|---|
| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| Gdf10 | growth differentiation factor 10 | UN | Gdf10 | ||||
| cat | E. coli chloramphenicol acetyltransferase (CAT) | UN | CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA) | ||||
| loxP | phage P1 loxP | UN | loxP | ||||
| loxP | phage P1 loxP | UN | loxP | ||||
| SV40 polyA | UN | ||||||
Phenotype | |
|---|---|
| Annotation by Mammalian phenotyhpe ontology | |
| Detailed phenotype data | |
Ordering Information | |
|---|---|
| Donor DNA | CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA), Phage P1 loxP sites, E. coli chloramphenicol acetyltransferase, mouse BMP-3b cDNA, SV40 polyA |
| Research application | Cre/loxP system Hematological Research Mouse Models for Human Disease |
| Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Int. J. Obes. (Lond)., 41(4):483-488 (2017). Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the Co-Developer (Ensyo Takuya) using the Approval Form. |
| Depositor | Mikiya Miyazato (National Cerebral and Cardiovascular Center) |
| Strain Status |  Frozen embryos Frozen sperm |
| Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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| No Data |