Strain Data Sheet
RBRC11533
Strain Information | |
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| Image | |
| BRC No. | RBRC11533 |
| Type | CRISPR/Cas9 |
| Species | Mus musculus |
| Strain name | B6D2F1;B6-Ets2<em1Aitn> |
| Former Common name | Ets2 em1 |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | |
| Appearance | |
| Strain development | Deposited by Ayako Isotani, Nara Institute of Science and Technology in 2021. This strain was generated using fertilized eggs derived from (C57BL/6 x DBA/2)F1 x C57BL/6J. Mixed genetic background. |
| Strain description | CRISPR/Cas9 technology generated a 205 bp deletion in exon 8. Skin and thymus show a mutant mRNA lacking exon 8 and protein lacking exon 8 is detected in the thymus. |
| Colony maintenance | |
| References | A novel tissue specific alternative splicing variant mitigates phenotypes in Ets2 frame-shift mutant models. Kishimoto Y, Nishiura I, Hirata W, Yuri S, Yamamoto N, Ikawa M, Isotani A Sci. Rep., 11(1):8297 (2021) 33859300 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |||||||
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| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| Ets2 MGI:95456 | E26 avian leukemia oncogene 2, 3' domain | 16 | Ets2<em1Aitn> MGI:6719263 | endonuclease-mediated mutation 1, Ayako Isotani | |||
Phenotype | |
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| Annotation by Mammalian phenotyhpe ontology | |
| Detailed phenotype data | |
Ordering Information | |
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| Donor DNA | |
| Research application | |
| Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Sci Rep. Apr 15;11(1):8297. (2021)For use of the BIOLOGICAL RESOURCE by a for-profit institution and an academic institution for the purpose of profits, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
| Depositor | Ayako Isotani (Nara Institute of Science and Technology) |
| Strain Status |  Frozen sperm |
| Strain Availability |  Recovery and QC required prior to distribution |
| Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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