Strain Data Sheet

RBRC11548

Strain Information

Image
BRC No.RBRC11548
TypeCRISPR/Cas9Cartagena
SpeciesMus musculus
Strain nameB6-Ntrk1<em1(E495K)Tkato>/KN2
Former Common nameB6J-Ntrk1 (CRISPR, 268-1); (PM+T)/+
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Tadafumi Kato, RIKEN CBS in 2021. This strain was generated using the CRISPR/Cas9. C57BL/6J genetic background.
Strain descriptionA damaging missense mutation E492K (rs144901788) reported in humans was introduced in the mouse Ntrk1 (TrkA) genomic region.
Colony maintenance
References
Exome sequencing in the knockin mice generated using the CRISPR/Cas system.
Nakajima K, Kazuno A A, Kelsoe J, Nakanishi M, Takumi T, Kato T
Sci. Rep., 6:34703 (2016). 27698470

Ntrk1 mutation co-segregating with bipolar disorder and inherited kidney disease in a multiplex family causes defects in neuronal growth and depression-like behavior in mice.
Nakajima K, Miranda A, Craig D W, Shekhtman T, Kmoch S, Bleyer A, Szelinger S, Kato T, Kelsoe J R
Transl. Psychiatry, 10, 407 (2020). 33235206

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ntrk1
MGI:97383		neurotrophic tyrosine kinase, receptor, type 13Ntrk1<em1(E495K)Tkato> endonuclease-mediated mutation 1, Tadafumi Kato
  • hereditary sensory and autonomic neuropathy type 4(DisGeNET, MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAStreptococcus pyogenes Cas9 mRNA, Streptococcus pyogenes sgRNA, マウス single strand oligo DNA (a part of Ntrk1 gene)
    Research applicationMouse Models for Human Disease
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Transl. Psychiatry, 10, 407 (2020).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorTadafumi Kato (RIKEN)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: CRISPR/Cas9 genome edited bioresources (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data