Strain Information | |
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Image | |
BRC No. | RBRC11552 |
Type | CRISPR/Cas9 |
Species | Mus musculus |
Strain name | B6-Ntrk1<em5Tkato>/KN6 |
Former Common name | B6J-Ntrk1 (CRISPR, KO); 3b Delta/+ |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Tadafumi Kato, RIKEN CBS in 2021. This strain was generated using the CRISPR/Cas9. C57BL/6J genetic background. |
Strain description | 3bp deletion at exon 12 of the Ntrk1 gene. |
Colony maintenance | |
References | Ntrk1 mutation co-segregating with bipolar disorder and inherited kidney disease in a multiplex family causes defects in neuronal growth and depression-like behavior in mice. Nakajima K, Miranda A, Craig D W, Shekhtman T, Kmoch S, Bleyer A, Szelinger S, Kato T, Kelsoe J R Transl. Psychiatry, 10, 407 (2020). 33235206Exome sequencing in the knockin mice generated using the CRISPR/Cas system. Nakajima K, Kazuno A A, Kelsoe J, Nakanishi M, Takumi T, Kato T Sci. Rep., 6:34703 (2016). 27698470 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Ntrk1 | neurotrophic tyrosine kinase, receptor, type 1 | 3 | Ntrk1 | endonuclease-mediated mutation 5, Tadafumi Kato |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | Streptococcus pyogenes Cas9 mRNA, Streptococcus pyogenes sgRNA, マウス single strand oligo DNA (a part of Ntrk1 gene) |
Research application | Mouse Models for Human Disease |
Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Transl. Psychiatry, 10, 407 (2020).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
Depositor | Tadafumi Kato (RIKEN) |
Strain Status | Frozen sperm |
Strain Availability | Recovery and QC required prior to distribution |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |