Strain Data Sheet
RBRC11554
Strain Information | |
|---|---|
| Image | |
| BRC No. | RBRC11554 |
| Type | Targeted Mutation Congenic |
| Species | Mus musculus |
| Strain name | B6.Cg-Bcl2l11<tm1.1Mtto> |
| Former Common name | Bim<f/f> |
| H-2 Haplotype | |
| ES Cell line | Bruce 4 [B6.Cg-Thy1<a>] |
| Background strain | |
| Appearance | |
| Strain development | Deposited by Toshitada Takemori, RIKEN in 2021. This strain was generated using Bruce 4 ES cells derived from B6.Cg-Thy1.1. C57BL/6 congenic line. Frt-flanked neo cassette was removed in this strain. |
| Strain description | Floxed Bcl2l11(Bim) mice. A pair of loxP flanks exon 5 of the Bcl2l11(Bim) gene. |
| Colony maintenance | |
| References | Bim establishes the B cell repertoire from early to late in the immune response. Sugimoto-Ishige A, Harada M, Tanaka M, Terooatea T, Adachi Y, Takahashi Y, Tanaka T, Burrows P D, Hikida M, Takemori T Int. Immunol., 33(2):79-90 (2021). 32889526 |
Health Report | |
|---|---|
| Examination Date / Room / Rack | 2025/03/10Room:3-5Rack:CSentinel mouse program 2024/12/09Room:3-5Rack:CSentinel mouse program 2024/09/09Room:3-5Rack:CSentinel mouse program 2024/06/10Room:3-5Rack:CSentinel mouse program |
Gene | |||||||
|---|---|---|---|---|---|---|---|
| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| Bcl2l11 MGI:1197519 | BCL2 like 11 | 2 | Bcl2l11<tm1.1Mtto> | targeted mutation 1.1, Toshitada Takemori | |||
| Frt | yeast FRT (flippase recombination target) site | 2 | Frt | ||||
| loxP | phage P1 loxP | 2 | loxP | ||||
Phenotype | |
|---|---|
| Annotation by Mammalian phenotyhpe ontology | |
| Detailed phenotype data | |
Ordering Information | |
|---|---|
| Donor DNA | Bacterial virus(Enterobacteria phage P1) loxP sites, Saccharomyces cerevisiae FRT sites, mouse Bcl2l11 genomic DNA |
| Research application | Cre/loxP system FLP/frt system |
| Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Int. Immunol., 33(2):79-90 (2021). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
| Depositor | Toshitada Takemori (RIKEN) |
| Strain Status |  Live mice Frozen embryos Frozen sperm |
| Strain Availability | Cryopreserved sperm (within 1 month) Live mouse (1 to 3 months) |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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| No Data |