Strain Information | |
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Image | |
BRC No. | RBRC11565 |
Type | CRISPR/Cas9 (Transgene)![]() |
Species | Mus musculus |
Strain name | C.Cg-Ace2<em1(ACE2)Okt> |
Former Common name | hACE2KI_NCGM |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Deposited by Tadashi Oakmura, National Center for Global Health and Medicine, NCGM in 2021. This strain was generated using fertilized eggs derived from Slc:BDF1 x C57BL/6JJcl. Mice were backcrossed to BALB/c for 8 generations. |
Strain description | Knockin mice of human ACE2 at the Ace2 locus. |
Colony maintenance | |
References | Identification of SARS-CoV-2 Mpro inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2. Nobuyo Higashi-Kuwata, Kohei Tsuji, Hironori Hayashi, Haydar Bulut, Maki Kiso, Masaki Imai, Hiromi Ogata-Aoki, Takahiro Ishii, Takuya Kobayakawa, Kenta Nakano, Nobutoki Takamune, Naoki Kishimoto, Shin-Ichiro Hattori, Debananda Das, Yukari Uemura, Yosuke Shimizu, Manabu Aoki, Kazuya Hasegawa, Satoshi Suzuki, Akie Nishiyama, Junji Saruwatari, Yukiko Shimizu, Yoshikazu Sukenaga, Yuki Takamatsu, Kiyoto Tsuchiya, Kenji Maeda, Kazuhisa Yoshimura, Shun Iida, Seiya Ozono, Tadaki Suzuki, Tadashi Okamura, Shogo Misumi, Yoshihiro Kawaoka, Hirokazu Tamamura, Hiroaki Mitsuya Nat. Commun., 14(1):1076 (2023). 36841831 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
ACE2 | angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (human) | X | ACE2 | ||||
Ace2 MGI:1917258 | angiotensin converting enzyme 2 | X | Ace2<em1(ACE2)Okt> | endonuclease-mediated mutation 1, Tadashi Okamura | |||
HBB2 | rabbit beta-globin polyA signal | X | HBB2 |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | human ACE2 cDNA, rabbit beta-globin poly(A) signal sequence, mouse Ace2 genomic DNA |
Research application | Immunology and Inflammation Research Virology Research covid19_infection |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat Commun., 14(1):1076 (2023). doi: 10.1038/s41467-023-36729-0. |
Depositor | Tadashi Okamura (National Center for Global Health and Medicine) |
Strain Status | ![]() ![]() |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |