Strain Information | |
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Image | |
BRC No. | RBRC11571 |
Type | Targeted Mutation![]() |
Species | Mus musculus |
Strain name | B6.129-Gba2<tm1Rus>/Yhir |
Former Common name | GBA2 KO |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Deposited by Hisako Akiyama in 2021 with permission from Dr. Dagmar Wachten. This strain was generated using ES cells derived from 129S6/SvEv and then backcrossed to C57BL/6J for 10 generations. |
Strain description | Gba2 knockout mice. Exons 5-10 are deleted. |
Colony maintenance | |
References | Mutation of beta-glucosidase 2 causes glycolipid storage disease and impaired male fertility. Yildiz Y, Matern H, Thompson B, Allegood J C, Warren R L, Ramirez D M, Hammer R E, Hamra F K, Matern S, Russell D W J. Clin. Invest., 116(11):2985-94 (2006). 17080196Glucocerebrosidases catalyze a transgalactosylation reaction that yields a newly-identified brain sterol metabolite, galactosylated cholesterol. Akiyama H, Ide M, Nagatsuka Y, Sayano T, Nakanishi E, Uemura N, Yuyama K, Yamaguchi Y, Kamiguchi H, Takahashi R, Aerts J M F G, Greimel P, Hirabayashi Y J. Biol. Chem., 295(16):5257-5277 (2020). 32144204 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Gba2 MGI:2654325 | glucosidase beta 2 | 4 | Gba2<tm1Rus> MGI:3691302 | targeted mutation 1, David W Russell | |||
loxP | phage P1 loxP | 4 | loxP |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | P1ファージ loxP |
Research application | Cre/loxP system |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Biol. Chem., 295(16):5257-5277 (2020). |
Depositor | Hiroyuki Kamiguchi (RIKEN CBS) |
Strain Status | ![]() ![]() |
Strain Availability | ![]() |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |