Strain Data Sheet
RBRC11679
Strain Information | |
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| Image | |
| BRC No. | RBRC11679 |
| Type | Targeted Mutation |
| Species | Mus musculus |
| Strain name | B6.129S-Nudt1<tm1Yun> |
| Former Common name | Mth1 KO |
| H-2 Haplotype | |
| ES Cell line | CCE/EK.CCE [129S/SvEv-Gpi1<c>] |
| Background strain | |
| Appearance | |
| Strain development | Deposited by Yusaki Nakabeppu, Kyusyu University in 2022. This strain was generated using CCE/EK.CCE ES Cell derived from 129S/SvEv-Gpi1<c> and then mice were backcrossed to C57BL/6J for 41 generations. C57BL/6J congenic strain. |
| Strain description | Nudt1 mutant mice. Exon 3 is replaced with a Neo fragment. |
| Colony maintenance | |
| References | Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase. T Tsuzuki, A Egashira, H Igarashi, T Iwakuma, Y Nakatsuru, Y Tominaga, H Kawate, K Nakao, K Nakamura, F Ide, S Kura, Y Nakabeppu, M Katsuki, T Ishikawa, M Sekiguchi Proc. Natl. Acad. Sci. USA, 98(20):11456-61(2001). 11572992 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |||||||
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| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| Nudt1 MGI:109280 | nudix hydrolase 1 | 5 | Nudt1<tm1Yun> | targeted mutation 1, Yusaku Nakabeppu | |||
| neo | neomycin resistance gene (E. coli) | 5 | |||||
Phenotype | |
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| Annotation by Mammalian phenotyhpe ontology | |
| Detailed phenotype data | |
Ordering Information | |
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| Donor DNA | mouse RNA polymerase II large subunit promoter, E. coli Neomycin resistant gene, mouse Hprt polyA signal, mouse Nudt1 genomic DNA |
| Research application | Cancer Research |
| Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA, 98(20):11456-61(2001). |
| Depositor | Yusaku Nakabeppu (Kyushu University) |
| Strain Status |  Frozen sperm |
| Strain Availability |  Recovery and QC required prior to distribution |
| Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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| No Data |