Strain Data Sheet

RBRC11680

Strain Information

Image
BRC No.RBRC11680
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S-Mutyh<tm1Yun>
Former Common nameMutyh KO
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strain
Appearance
Strain developmentDeposited by Yusaki Nakabeppu, Kyusyu University in 2022. This strain was generated using CCE/EK.CCE ES Cell derived from 129S/SvEv-Gpi1<c> and then mice were backcrossed to C57BL/6J for 46 generations. C57BL/6J congenic strain.
Strain descriptionMutyh mutant mice. A Neo fragment replaced exon 8-15.
Colony maintenance
References
MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis.
Katsumi Sakamoto, Yohei Tominaga, Kazumi Yamauchi, Yoshimichi Nakatsu, Kunihiko Sakumi, Kaoru Yoshiyama, Akinori Egashira, Shinobu Kura, Takashi Yao, Masazumi Tsuneyoshi, Hisaji Maki, Yusaku Nakabeppu, Teruhisa Tsuzuki
Cancer Res., 67(14):6599-604 (2007). 17638869

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Mutyh
MGI:1917853		mutY DNA glycosylase4Mutyh<tm1Yun>
MGI:5476928		targeted mutation 1, Yusaku Nakabeppu
  • familial adenomatous polyposis 2(MedGEN)

  • gastric cancer(MedGEN)
    • neo neomycin resistance gene (E. coli)4

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAmouse RNA polymerase II large subunit promoter, E. coli Neomycin resistant gene, mouse Hprt polyA signal
    Research applicationCancer Research
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cancer Res., 67(14):6599-604 (2007).
    DepositorYusaku Nakabeppu (Kyushu University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data