Strain Data Sheet

RBRC11685

Strain Information

Image
BRC No.RBRC11685
TypeCRISPR/Cas9Cartagena
SpeciesMus musculus
Strain nameC57BL/6-Tgfb1<em1Rlcpu>
Former Common nameTgfB1 PLK KI mouse
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
LAP degradation product reflects plasma kallikrein-dependent TGF-β activation in patients with hepatic fibrosis.
Mitsuko Hara, Akiko Kirita, Wakako Kondo, Tomokazu Matsuura, Keisuke Nagatsuma, Naoshi Dohmae, Shinji Ogawa, Shinobu Imajoh-Ohmi, Scott L Friedman, Daniel B Rifkin, Soichi Kojima
Springerplus, 3:221 (2014). 24877031

L(59) TGF-β LAP degradation products serve as a promising blood biomarker for liver fibrogenesis in mice.
Mitsuko Hara, Ikuyo Inoue, Yuta Yamazaki, Akiko Kirita, Tomokazu Matsuura, Scott L Friedman, Daniel B Rifkin, Soichi Kojima
Fibrogenesis Tissue Repair., 8:17 (2015). 26379781

Health Report

Examination Date / Room / Rack2024/05/20Room:4-ARack:JSentinel mouse program
2024/02/19Room:4-ARack:JSentinel mouse program
2023/11/20Room:4-ARack:JSentinel mouse program
2023/08/21Room:4-ARack:JSentinel mouse program
2023/05/22Room:4-ARack:JSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tgfb1
MGI:98725		transforming growth factor, beta 17Tgfb1<em1Rlcpu> endonuclease-mediated mutation 1, Yutaka Furutani
  • Camurati-Engelmann disease(DisGeNET, MedGEN)

  • cystic fibrosis(MedGEN)

  • inflammatory bowel disease, immunodeficiency, and encephalopathy(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAmouse Tgfb1
    Research application
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
    DepositorYutaka Furutani (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: CRISPR/Cas9 genome edited bioresources (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data