Strain Information | |
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Image | |
BRC No. | RBRC11687 |
Type | CRISPR/Cas9 (Transgene)![]() |
Species | Mus musculus |
Strain name | B6;Cg-Oxtr<em2(1xPA/T2A/icre)Yinn> |
Former Common name | Oxtr<1xPA-iCre> |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Deposited by Yukiko U. Inoue and Takayoshi Inoue, National Center of Neurology and Psychiatry in 2022. This strain was generated using fertilized eggs derived from (C57BL/6 x C3H)F1. Mixed genetic background. |
Strain description | icre knockin mice via 1xPA/T2A at the C-terminus of the Oxtr gene. Homozygous mice are fertile. |
Colony maintenance | |
References | Targeting Neurons with Functional Oxytocin Receptors: A Novel Set of Simple Knock-In Mouse Lines for Oxytocin Receptor Visualization and Manipulation. Yukiko U Inoue, Hideki Miwa, Kei Hori, Ryosuke Kaneko, Yuki Morimoto, Eriko Koike, Junko Asami, Satoshi Kamijo, Mitsuhiko Yamada, Mikio Hoshino, Takayoshi Inoue eNeuro, 9(1):ENEURO.0423-21.2022 (2022). 35082173Parallel labeled-line organization of sympathetic outflow for selective organ regulation in mice. Yukiko Harima, Masafumi Tsurutani, Serika Yamada, Shuntaro Uchida, Kengo Inada, Mitsue Hagihara, Satsuki Irie, Mayo Shigeta, Takaya Abe, Yukiko U Inoue, Takayoshi Inoue, Kazunari Miyamichi Nat. Commun., 15(1):10478 (2024). 39658565 |
Health Report | |
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Examination Date / Room / Rack | 2024/11/25Room:4-CRack:FSentinel mouse program 2024/08/26Room:4-CRack:FSentinel mouse program 2024/05/27Room:4-CRack:FSentinel mouse program 2024/02/26Room:4-CRack:FSentinel mouse program 2023/11/27Room:4-CRack:FSentinel mouse program 2023/08/28Room:4-CRack:FSentinel mouse program 2023/05/29Room:4-CRack:FSentinel mouse program 2023/02/27Room:4-CRack:FSentinel mouse program |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Oxtr MGI:109147 | oxytocin receptor | 6 | Oxtr<em2(1xPA/T2A/icre)Yinn> | endonuclease-mediated mutation 2, Yukiko U Inoue | |||
PA | PA tag (GVAMPGAEDDVV) (synthetic) human Podoplanin | 6 | PA | ||||
T2A | Thosea asigna virus 2A peptide (insect) | 6 | T2A | ||||
icre | phage P1 codon improved Cre (iCre) | 6 | icre | ||||
nls | SV40 large T antigen nuclear localization signal (NLS) | 6 | nls |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | human Podoplanin PA-tag sequence, Thosea asigna virus 2A peptide (insect), SV40 nls, Phage P1 Cre (codon-improved Cre recombinase) |
Research application | Cre/loxP system |
Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. eNeuro, 9(1):ENEURO.0423-21.2022 (2022) For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Takayoshi Inoue (National Center of Neurology and Psychiatry) |
Strain Status | ![]() ![]() ![]() |
Strain Availability | Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) Live mouse (1 to 3 months) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- Mouse of the Month Sep 2023 |
BRC mice in Publications |
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No Data |