Strain Data Sheet

RBRC11712

Strain Information

Image
BRC No.RBRC11712
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6;Cg-Sox2<tm1.1(cre/ERT2)Ykaw>
Former Common nameSox2 CreERT2
H-2 Haplotype
ES Cell lineV6.5 [(C57BL/6J x 129S4/SvJae)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Epithelial expression of Gata4 and Sox2 regulates specification of the squamous-columnar junction via MAPK/ERK signaling in mice.
Nao Sankoda, Wataru Tanabe, Akito Tanaka, Hirofumi Shibata, Knut Woltjen, Tsutomu Chiba, Hironori Haga, Yoshiharu Sakai, Masaki Mandai, Takuya Yamamoto, Yasuhiro Yamada, Shinji Uemoto, Yoshiya Kawaguchi
Nat. Commun., 12(1):560 (2021). 33495473

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
ERT2 estrogen receptor (ER), human ER with the triple mutation G400V/M543A/L544A)3ERT2
Sox2
MGI:98364
SRY (sex determining region Y)-box 23Sox2<tm1.1(cre/ERT2)Ykaw> targeted mutation 1.1, Yoshiya Kawaguchi
  • anophthalmia/microphthalmia-esophageal atresia syndrome(MedGEN)
  • cre Phage P1 Cre recombinase3cre

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAP1 Bacteriophage Cre, human Estrogen receptor binding domain (ERT2)cDNA, Rabbit (globin) (CreERT2-)pA, D6 Bacteriophage rox
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Commun., 12(1):560 (2021). doi: 10.1038/s41467-021-20906-0. 1) BIOLOGICAL RESOURCE must be used for academic research purpose conducted by the RECIPIENT who belongs to a non-profit academic organization, (i.e. a university or another institution of higher education or any non-profit scientific or educational organization, including government agencies.) 2) The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from KYOTO UNIVERSITY (Contact address: Contract Management Office, CiRA Foundation Email: cont-g@cira-foundation.or.jp). 3) The RECIPIENT must contact KYOTO UNIVERSITY (Contact address: Contract Management Office, CiRA Foundation Email: cont-g@cira-foundation.or.jp) in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
    DepositorYoshiya Kawaguchi (Kyoto University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Cre-ERT(2): NOTICE TO RECIPIENT
    5. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data