Strain Data Sheet

RBRC11713

Strain Information

Image
BRC No.RBRC11713
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129-Polb<tm1Koy>
Former Common namePol-BETA
H-2 Haplotype
ES Cell lineBK4 [129P2/OlaHsd]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase beta.
N Sugo, Y Aratani, Y Nagashima, Y Kubota, H Koyama
EMBO J., 19(6):1397-404 (2000). 10716939

p53 Deficiency rescues neuronal apoptosis but not differentiation in DNA polymerase beta-deficient mice.
Noriyuki Sugo, Naoko Niimi, Yasuaki Aratani, Keiko Takiguchi-Hayashi, Hideki Koyama
Mol. Cell Biol., 24(21):9470-7 (2004). 15485914

Decreased PARP-1 levels accelerate embryonic lethality but attenuate neuronal apoptosis in DNA polymerase beta-deficient mice.
Noriyuki Sugo, Naoko Niimi, Yasuaki Aratani, Mitsuko Masutani, Hiroshi Suzuki, Hideki Koyama
Biochem. Biophys. Res. Commun., 354(3):656-61(2007). 17257586

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Polb
MGI:97740
polymerase (DNA directed), beta8Polb<tm1Koy>
MGI:2386539
targeted mutation 1, Hideki Koyama
neo neomycin resistance gene (E. coli)8 mouse phosphoglycerate kinase promoter (PGK promoter)
SV40 polyA8

Phenotype

Annotation by Mammalian phenotyhpe ontology
Detailed phenotype data

Ordering Information

Donor DNAマウス PGK プロモーター, E.coli ネオマイシン耐性遺伝子, SV40 ポリA付加シグナル
Research application
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. EMBO J., 19(6):1397-404 (2000).Only available to nonprofit for academic research purposes. When use by commercial institution or used by a non-profit institution for commercial purposes, it is necessary to conclude a license agreement with Yokohama City University ("YCU", contact: ip@yokohama-cu.ac.jp), which is the right holder for the BIOLOGICAL RESOURCE. The RECIPIENT must contact YCU in the case of application for any patents or commercial use based on the patents obtained from the use of the BIOLOGICAL RESOURCE.
DepositorNoriyuki Sugo (Osaka University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data