Strain Information | |
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Image | |
BRC No. | RBRC11713 |
Type | Targeted Mutation![]() |
Species | Mus musculus |
Strain name | B6.129-Polb<tm1Koy> |
Former Common name | Pol-BETA |
H-2 Haplotype | |
ES Cell line | BK4 [129P2/OlaHsd] |
Background strain | |
Appearance | |
Strain development | |
Strain description | |
Colony maintenance | |
References | Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase beta. N Sugo, Y Aratani, Y Nagashima, Y Kubota, H Koyama EMBO J., 19(6):1397-404 (2000). 10716939p53 Deficiency rescues neuronal apoptosis but not differentiation in DNA polymerase beta-deficient mice. Noriyuki Sugo, Naoko Niimi, Yasuaki Aratani, Keiko Takiguchi-Hayashi, Hideki Koyama Mol. Cell Biol., 24(21):9470-7 (2004). 15485914Decreased PARP-1 levels accelerate embryonic lethality but attenuate neuronal apoptosis in DNA polymerase beta-deficient mice. Noriyuki Sugo, Naoko Niimi, Yasuaki Aratani, Mitsuko Masutani, Hiroshi Suzuki, Hideki Koyama Biochem. Biophys. Res. Commun., 354(3):656-61(2007). 17257586 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Polb MGI:97740 | polymerase (DNA directed), beta | 8 | Polb<tm1Koy> MGI:2386539 | targeted mutation 1, Hideki Koyama | |||
neo | neomycin resistance gene (E. coli) | 8 | mouse phosphoglycerate kinase promoter (PGK promoter) | ||||
SV40 polyA | 8 |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | マウス PGK プロモーター, E.coli ネオマイシン耐性遺伝子, SV40 ポリA付加シグナル |
Research application | |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. EMBO J., 19(6):1397-404 (2000).Only available to nonprofit for academic research purposes. When use by commercial institution or used by a non-profit institution for commercial purposes, it is necessary to conclude a license agreement with Yokohama City University ("YCU", contact: ip@yokohama-cu.ac.jp), which is the right holder for the BIOLOGICAL RESOURCE. The RECIPIENT must contact YCU in the case of application for any patents or commercial use based on the patents obtained from the use of the BIOLOGICAL RESOURCE. |
Depositor | Noriyuki Sugo (Osaka University) |
Strain Status | ![]() |
Strain Availability | ![]() |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |