Strain Data Sheet

RBRC11719

Strain Information

Image
BRC No.RBRC11719
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S-Vim<tm1Sibg>
Former Common nameVIM<SA/SA>
H-2 Haplotype
ES Cell lineEB3 [129/Ola]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Defect of mitotic vimentin phosphorylation causes microophthalmia and cataract via aneuploidy and senescence in lens epithelial cells.
Makoto Matsuyama, Hiroki Tanaka, Akihito Inoko, Hidemasa Goto, Shigenobu Yonemura, Kyoko Kobori, Yuko Hayashi, Eisaku Kondo, Shigeyoshi Itohara, Ichiro Izawa, Masaki Inagaki
J. Biol. Chem., 288(50):35626-35 (2013). 24142690

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Vim
MGI:98932
vimentin2Vim<tm1Sibg>
MGI:6355955
targeted mutation 1, Shigeyoshi Itohara
  • cataract 30(DisGeNET, MedGEN)
  • loxP phage P1 loxP2loxP
    loxP phage P1 loxP2loxP
    neo neomycin resistance gene (E. coli)2

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAphage P1 loxP sites, mouse phosphoglycerate kinase promoter (PGK promoter), E.coli Neomycin resistant gene, mouse Vim genomic DNA
    Research applicationCre/loxP system
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Biol. Chem., 288(50):35626-35 (2013).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Masaki Inagaki is requested.
    DepositorDaishi Yamakawa (Mie University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data