Strain Data Sheet

RBRC11809

Strain Information

Image
BRC No.RBRC11809
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain name129S6/SvEv-Mir124a-1hg<tm1Tfur>
Former Common namemiR-124a-1 KO
H-2 Haplotype
ES Cell lineTC1 [129S6/SvEvTac]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression.
Sanuki R, Onishi A, Koike C, Muramatsu R, Watanabe S, Muranishi Y, Irie S, Uneo S, Koyasu T, Matsui R, Cherasse Y, Urade Y, Watanabe D, Kondo M, Yamashita T, Furukawa T
Nat. Neurosci., 14(9) 1125-34 (2011). 21857657

Health Report

Examination Date / Room / Rack2024/11/25Room:4-CRack:HSentinel mouse program
2024/05/27Room:4-CRack:HSentinel mouse program
2024/02/26Room:4-CRack:HSentinel mouse program
2023/11/27Room:4-CRack:HSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Mir124a-1hg
MGI:2442197		Mir124-1 host gene (non-protein coding)14Mir124a-1hg<tm1Tfur>
MGI:5307015		targeted mutation 1, Takahisa Furukawa
neo neomycin resistance gene (E. coli)14
SV40 polyA signal14

Phenotype

Annotation by Mammalian phenotyhpe ontology
Detailed phenotype data

Ordering Information

Donor DNAMouse PGK promoter, E. coli Neomycin resistance gene, SV40 PolyA signal, Mouse Rncr3 locus
Research applicationNeurobiology Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Neurosci., 14(9):1125-34 (2011). doi: 10.1038/nn.2897.The RECIPIENT must contact to the DEPOSITOR and contact an MTA with Osaka University.
DepositorTakahisa Furukawa (Osaka University)
Strain Statusan icon for Live miceLive mice
an icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityCryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Live mouse (1 to 3 months)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

No Data