Strain Data Sheet

RBRC11908

Strain Information

Image
BRC No.RBRC11908
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6;Cg-Pycr2<tm1Hmd>
Former Common namePycr2 KO(C07)
H-2 Haplotype
ES Cell lineG4 [(129S6/SvEvTac x C57BL/6NCr)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2.
Nathalie Escande-Beillard, Abigail Loh, Sahar N Saleem, Kohei Kanata, Yui Hashimoto, Umut Altunoglu, Artina Metoska, Joanes Grandjean, Fui Mee Ng, Oz Pomp, Nithya Baburajendran, Joyner Wong, Jeffrey Hill, Emmanuel Beillard, Patrick Cozzone, Maha Zaki, Hülya Kayserili, Hiroshi Hamada, Hidetaka Shiratori, Bruno Reversade
Neuron, 107(1):82-94.e6.(2020). 32330411

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Frt yeast FRT (flippase recombination target) site1Frt
Pycr2
MGI:1277956		pyrroline-5-carboxylate reductase family, member 21Pycr2<tm1Hmd> targeted mutation 1.1, Hiroshi Hamada
  • hypomyelinating leukodystrophy 10(MedGEN)
    • neo neomycin resistance gene (E. coli)1

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAマウス PGK プロモーター, 大腸菌 ネオマイシン耐性遺伝子, 酵母 Frt 配列
    Research applicationFLP/frt system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Neuron. Jul 8;107(1):82-94.e6.(2020) doi: 10.1016/j.neuron.2020.03.028.In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorHiroshi Hamada (RIKEN)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data