Strain Data Sheet

RBRC12070

Strain Information

Image
BRC No.RBRC12070
TypeCRISPR/Cas9Cartagena
SpeciesMus musculus
Strain nameMCH.B6C3F1-Dll1<em1Yoku>
Former Common nameNon-cleavable Dll1 mouse
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Cleaved Delta like 1 intracellular domain regulates neural development via Notch signal-dependent and -independent pathways.
Yusuke Okubo, Fumiaki Ohtake, Katsuhide Igarashi, Yukuto Yasuhiko, Yoko Hirabayashi, Yumiko Saga, Jun Kanno
Development, 148 (19): dev193664 (2021). 34519339

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Dll1
MGI:104659		delta like canonical Notch ligand 117Dll1<em1Yoku> endonuclease-mediated mutation 1, Yusuke Okubo
  • neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAStreptococcus pyogenes crRNA, Streptococcus pyogenes tracrRNA, Mouse a part of Delta like 1 gene
    Research applicationDevelopmental Biology Research
    Neurobiology Research
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Development, 148 (19): dev193664 (2021).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorYusuke Okubo (National Institute of Health Sciences)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: CRISPR/Cas9 genome edited bioresources (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data