Strain Data Sheet

RBRC12086

Strain Information

Image
BRC No.RBRC12086
TypeTransgene CongenicCartagena
SpeciesMus musculus
Strain nameD1.Cg-Tg(Col2a1-CIITA)1Skncu Tg(Col2a1-Cd80)1Skncu Igs7<em1(Scgb1a1-mCherry)Skncu>
Former Common nameD1CC x D1BC x mCherry (DBA/1, Collagen type II promoter/ enhancer-driven CIITA, DBA/1, theB7.1 gene is transcribed from the rat collagen Type II promoter and enhancer)
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Aberrant MHC class II expression in mouse joints leads to arthritis with extraarticular manifestations similar to rheumatoid arthritis.
Kanazawa S, Ota S, Sekine C, Tada T, Otsuka T, Okamoto T, Sonderstrup G, Peterlin B M
Proc. Natl. Acad. Sci. USA, 103(39):14465-70 (2006). 16980409

A Subpopulation of Synovial Fibroblasts Leads to Osteochondrogenesis in a Mouse Model of Chronic Inflammatory Rheumatoid Arthritis.
Yoko Miura, Shusuke Ota, Matija Peterlin, Grete McDevitt, Satoshi Kanazawa
JBMR Plus, 3(6):e10132 (2019). 31346564

Bimodal fibrosis in a novel mouse model of bleomycin-induced usual interstitial pneumonia.
Yoko Miura, Maggie Lam, Jane E Bourke, Satoshi Kanazawa
Life Sci. Alliance, 5(1):e202101059 (2021). 34728556

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Igs7
MGI:5490612		intergenic site 79Igs7<em1(Scgb1a1-mCherry)Skncu> endonuclease mediated mutation 1,
CIITA class II transactivatorUNCIITA rat Col2a1 Promoter, enhancer
Cd80 CD80 antigenUNCd80
HA human influenza virus HA (hemagglutinin) tag sequenceUNHA
mCherry Red Fluorescent Protein (Discosoma sp.)UNmCherry
puro puromycin acyltransferase (Streptomyces alboniger)UNpuro
SV40 polyAUN

Phenotype

Annotation by Mammalian phenotyhpe ontology
Detailed phenotype data

Ordering Information

Donor DNAヒト CIITA(cDNA): D1CC locus, ウサギ Globin splicing sequence: D1CC locus, ラット Type II collagen Promoter, enhancer: D1CC and D1BClocus, ウシシミアンウイルス 40 PolyA: D1CC and D1BC locus, インフルエンザウイルス HA: D1CC locus, Klebsella pneumonia Neomycin 耐性遺伝子: D1CC locus, ラット、マウス B7.1(cDNA+CIITA PolyA): D1BC locus, Streptomyces alboniger Puromycin 耐性遺伝子: D1BC locus, マウス CC10 promoter: TIGRE locus, イソギンチャク由来 DsRed改変遺伝子 ｍCherry: TIGRE locus
Research applicationFluorescent Proteins/lacZ System
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. U S A., 103(39):14465-70 (2006). JBMR Plus, 3(6):e10132 (2019). Life Sci. Alliance, 5(1):e202101059 (2021).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
DepositorSatoshi Kanazawa (Nagoya City University)
Strain Statusan icon for Live miceLive mice
an icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovery and QC required prior to distribution
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: FP license of TBUSA
  4. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

No Data