Strain Data Sheet

RBRC12101

Strain Information

Image
BRC No.RBRC12101
TypeCRISPR/Cas9Cartagena
SpeciesMus musculus
Strain nameB6.Cg-Dnmt3a<em2(D329A)Hsas>
Former Common nameDnmt3a D329A
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
The DNMT3A PWWP domain is essential for the normal DNA methylation landscape in mouse somatic cells and oocytes.
Kanako Kibe, Kenjiro Shirane, Hiroaki Ohishi, Shuhei Uemura, Hidehiro Toh, Hiroyuki Sasaki
PLoS Genet., 17(5):e1009570 (2021). 34048432

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Dnmt3a
MGI:1261827		DNA methyltransferase 3A12Dnmt3a<em2(D329A)Hsas> endonuclease-mediated mutation 2, Hiroyuki Sasaki
  • acute myeloid leukemia(DisGeNET, MedGEN)

  • Heyn-Sproul-Jackson syndrome(MedGEN)

  • Tatton-Brown-Rahman overgrowth syndrome(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAMouse A part of Dnmt3a gene, Streptococcus pyogenes gRNA, Cas9
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. PLoS Genet., 17(5):e1009570 (2021).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorHiroyuki Sasaki (Kyushu University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: CRISPR/Cas9 genome edited bioresources (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data