Strain Data Sheet
RBRC12184
Strain Information | |
|---|---|
| Image | |
| BRC No. | RBRC12184 |
| Type | Targeted Mutation Congenic |
| Species | Mus musculus |
| Strain name | B6.Cg-Bdnf<tm1.1(tetO)Kftnk> |
| Former Common name | BDNF tetO knockin |
| H-2 Haplotype | |
| ES Cell line | G0G1 |
| Background strain | |
| Appearance | |
| Strain development | |
| Strain description | |
| Colony maintenance | |
| References | Downregulation of Bdnf Expression in Adult Mice Causes Body Weight Gain. Toru Suzuki, Kenji F Tanaka Neurochem Res., 47(9):2645-2655 (2022). 34982395Brain-derived neurotrophic factor from microglia regulates neuronal development in the medial prefrontal cortex and its associated social behavior. Takashi Komori, Kazuya Okamura, Minobu Ikehara, Kazuhiko Yamamuro, Nozomi Endo, Kazuki Okumura, Takahira Yamauchi, Daisuke Ikawa, Noriko Ouji-Sageshima, Michihiro Toritsuka, Ryohei Takada, Yoshinori Kayashima, Rio Ishida, Yuki Mori, Kohei Kamikawa, Yuki Noriyama, Yuki Nishi, Toshihiro Ito, Yasuhiko Saito, Mayumi Nishi, Toshifumi Kishimoto, Kenji F Tanaka, Noboru Hiroi, Manabu Makinodan Mol. Psychiatry, 29(5):1338-1349 (2024). 38243072 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |||||||
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| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| Bdnf MGI:88145 | brain derived neurotrophic factor | 2 | Bdnf<tm1.1(tetO)Kftnk> | targeted mutation 1, Kenji Tanaka | |||
| Frt | yeast FRT (flippase recombination target) site | 2 | Frt | ||||
| loxP | phage P1 loxP | 2 | loxP | ||||
| loxP | phage P1 loxP | 2 | loxP | ||||
| tetO | tetracycline operator (E. coli) | 2 | tetO | ||||
Phenotype | |
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| Annotation by Mammalian phenotyhpe ontology | |
| Detailed phenotype data | |
Ordering Information | |
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| Donor DNA | yeast FRT (flippase recombination target) site, E. coli Tetracycline operator site, サイトメガロウイルス CMV 最小プロモーター、phage P1 loxP sites, mouse Bdnf genomic DNA |
| Research application | Tet system |
| Specific Term and Conditions | No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.) |
| Depositor | Kenji Tanaka (Keio University) |
| Strain Status |  Frozen sperm |
| Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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| No Data |