Strain Data Sheet

RBRC12193

Strain Information

Image
BRC No.RBRC12193
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Mpo<tm1Mae>
Former Common nameMPO
H-2 Haplotype
ES Cell lineBK4 [129P2/OlaHsd]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Severe impairment in early host defense against Candida albicans in mice deficient in myeloperoxidase.
Y Aratani, H Koyama, S Nyui, K Suzuki, F Kura, N Maeda
Infect. Immun., 67 (4) 1828-36 (1999). 10085024

Differential host susceptibility to pulmonary infections with bacteria and fungi in mice deficient in myeloperoxidase.
Y Aratani, F Kura, H Watanabe, H Akagawa, Y Takano, K Suzuki, N Maeda, H Koyama
J. Infect. Dis. 182, 1276-1279 (2000). 10979934

Severe neutrophil-mediated lung inflammation in myeloperoxidase-deficient mice exposed to zymosan.
Kazuhiro Takeuchi, Yu Umeki, Noriko Matsumoto, Kei Yamamoto, Mina Yoshida, Kazuo Suzuki, Yasuaki Aratani
Inflamm. Res., 61, 197-205 (2012). 22116298

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Mpo
MGI:97137		myeloperoxidase11Mpo<tm1Mae>
MGI:2176344		targeted mutation 1, Nobuyo Maeda
  • Alzheimer disease type 1(MedGEN)

  • myeloperoxidase deficiency(DisGeNET, MedGEN)
    • neo neomycin resistance gene (E. coli)11

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAE.coli ネオマイシン耐性遺伝子
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Infect. Immun. 67: 1828-1836 (1999).The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorYasuaki Aratani (Yokohama City University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data