Cooperative effects of integrins and growth factor receptors on ERK signal duration
Initiation of integrin signaling by cell adhesion to an extracellular matrix (ECM) results in a transient and relatively weak activation ERK while initiation of receptor tyrosine kinase signaling by strongly mitogenic concentrations of growth factors (GF) results in a strong, transient ERK signal sufficient to induce p21cip1. The sustained ERK signal associated with the induction of cyclin D1 arises from a cooperative effect between receptor tyrosine kinases and integrins. (Contributed by Dr. Koji Nakade)
Human Resources
| Icon | Locus | Gene Products | Alternative Name |
|---|---|---|---|
| CYCLIN D1 | CCND1 | cyclin D1 | BCL1|D11S287E|PRAD1|U21B31 |
| CDK4 | CDK4 | cyclin-dependent kinase 4 | CMM3|MGC14458|PSK-J3 |
| p21 | CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 |
| ERK | MAPK1 | mitogen-activated protein kinase 1 | ERK|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk |
| ERK | MAPK3 | mitogen-activated protein kinase 3 | ERK1|HS44KDAP|HUMKER1A|MGC20180|P44ERK1|P44MAPK|PRKM3 |
Other Resources
| Locus | RDB no. | Type | Name of clone | Running title |
|---|---|---|---|---|
| Mapk1 | 2545 | ShuttleVector | pAxCAmERK2 (reverse) | Shuttle vector to generate rAd harboring mouse ERK2 |
| Mapk1 | 2544 | ShuttleVector | pAxCAmERK2 (forward) | Shuttle vector to produce rAd expressing mouse extracellular signal-regulated kinase 2 (ERK2) |
| Mapk1 | 1796 | DNA clone | pZRmERK2 cDNA | Mouse ERK2 cDNA |
| Cdk4 | 6971 | DNA clone | H3147D06 | Cdk4, NIA/NIH Mouse 15K cDNA Clone |
(GSB0004e, T.M.)
2023.06.08
